Which process is described as disintegration?

Which process is described as disintegration?

• A. The breakdown of oral drug into smaller particles
• B. The process of forming a solution from a drug
• C. Movement from the GI tract into bloodstream
• D. The fraction of the administered dose reaches systemic circulation

Answer: (A)

Disintegration is the physical breakup of a solid oral dosage form into smaller particles when it comes into contact with gastrointestinal fluids. This step prepares the drug for dissolution by increasing surface area, which then allows the drug to dissolve more readily. Forming a solution from a drug is dissolution, not disintegration. Movement from the GI tract into the bloodstream is absorption, and the fraction of the administered dose that reaches systemic circulation is bioavailability. So the description fits disintegration because it describes the solid dosage form breaking apart before it dissolves.

Disintegration is the physical breakup of a solid oral dosage form into smaller particles when it comes into contact with gastrointestinal fluids. This step prepares the drug for dissolution by increasing surface area, which then allows the drug to dissolve more readily. Forming a solution from a drug is dissolution, not disintegration. Movement from the GI tract into the bloodstream is absorption, and the fraction of the administered dose that reaches systemic circulation is bioavailability. So the description fits disintegration because it describes the solid dosage form breaking apart before it dissolves.